Diagnostic Methods for Detection of Cotinine Level in Tobacco Users: A Review
Published: March 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/.7423
Mitali Raja, Aarti Garg, Pramod Yadav, Kunal Jha, Sahil Handa
1. Senior Lecturer, Department of Public Health Dentistry, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India.
2. Senior Lecturer, Department of Pedodontics and Preventive Dentistry, Jaipur Dental College, Jaipur, India.
3. Assistant Professor, Department of Periodontology and Public Health Dentistry, Dr ZA Dental College, AMU, Aligarh, India.
4. Senior Lecturer, Department of Public Health Dentistry, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneshwar, India.
5. Senior Lecturer, Department of Public Health Dentistry, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
Correspondence
Dr. Mitali Raja,
M.I.G 24 Awas Vikas Scheme No.1 Kailash Vihar Kalyanpur Kanpur-208017, India.
E-mail: drmitaliraja@gmail.com
The greatest disease-producing product known to man is tobacco. It is a cause of many oral diseases and adverse oral conditions. In India, tobacco is available in smokeless and smoking form. Tobacco contains nicotine which metabolises to form a toxic alkaloid i.e. cotinine. It stimulates autonomic ganglia and central nervous system. Cotinine is the best indicator of tobacco smoke exposure. Various methods are used to measure cotinine level in blood, saliva and urine such as high performance liquid chromatography, colorimetric assay, gas chromatography, NicAlert saliva test, etc. Thus such wide range of methods for cotinine detection in tobacco users requires a detailed discussion regarding their utility. This review will help readers to compare various methods for cotinine detection and enable them to make scientifically informative decision.
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